Effekte eines kombinierten Ausdauer- und Krafttrainings auf die Muskelkraft während der Intensivtherapie in der pädiatrischen Onkologie: Ergebnisse einer randomisiert kontrollierten Studie

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Reduced muscle mass and strength are commonly observed in cancer patients. However, muscle function is known to be related to better treatment outcome and prognosis in oncologic diseases. Positive effects on muscle function were shown after specific exercise training in adult cancer patients. Further, this was related to better physical and mental health of the patients. Nevertheless, in children and adolescents with cancer the level of evidence in this field is sparse. In the present study, effects from combined resistance and endurance training were evaluated during intensive treatment in regular care of pediatric oncology. Within a randomized controlled study design, pediatric patients suffering from an oncological disease were included. Patients from the exercise group (EG) participated in supervised training whereas patients from the control group (CG) received usual care without additional supervised training.
In total, 33 patients, aged from 4.1 to 17.7 years, of whom 20 were boys, participated in the study. Patients from the EG exercised 2.7 ± 1.2 times weekly over a period of time of 8.0 ± 2.0 weeks. Results showed significant group-time-interactions in favor to the EG for knee flexor strength (p = 0.027), six-minute-walking-performance (p = 0.049), patients’ fatigue level rated by their parents (total score p = 0.013, sub-score fatigue p = 0.018, sub-score mental fatigue p = 0.046), patients’ self-reported quality of life (sub-score self-confidence p = 0.040, individual question concerning strength and endurance p = 0.046) and self-reported physical activity level (p = 0.014). Further, significant decrease of fatigue from pre- to posttest was reported from patients from the EG (p = 0.026), but not from patients from the CG. No significant group-time-interactions were observed for arm strength, body composition, patients’ self-reported fatigue level and children’s quality of life rated by their parents.
The performed intervention showed positive effects from training in pediatric oncology. Based on the present findings, a further optimization of adapted exercise programs in pediatric oncology is worthwhile in order to contribute to better quality of life in children with cancer.
Original languageGerman
Place of PublicationKöln
PublisherDeutsche Sporthochschule Köln
Number of pages70
Publication statusPublished - 2019

ID: 5116009

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