Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction

Research output: Contribution to journalJournal articlesResearch

Standard

Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction. / Schmidt, Annette; Wenzel, Daniela; Thorey, Irmgard; Sasaki, Takako; Hescheler, Jürgen; Timpl, Rupert; Addicks, Klaus; Werner, Sabine; Fleischmann, Bernd K; Bloch, Wilhelm.

In: Microvascular research, Vol. 71, No. 3, 01.05.2006, p. 152-162.

Research output: Contribution to journalJournal articlesResearch

Harvard

Schmidt, A, Wenzel, D, Thorey, I, Sasaki, T, Hescheler, J, Timpl, R, Addicks, K, Werner, S, Fleischmann, BK & Bloch, W 2006, 'Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction', Microvascular research, vol. 71, no. 3, pp. 152-162. https://doi.org/10.1016/j.mvr.2006.01.001

APA

Schmidt, A., Wenzel, D., Thorey, I., Sasaki, T., Hescheler, J., Timpl, R., Addicks, K., Werner, S., Fleischmann, B. K., & Bloch, W. (2006). Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction. Microvascular research, 71(3), 152-162. https://doi.org/10.1016/j.mvr.2006.01.001

Vancouver

Bibtex

@article{2867bec98e9743fbb0c60434c8a82f6d,
title = "Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction",
abstract = "Endostatin, the proteolytic fragment of collagen XVIII, is known to be a potent inhibitor of angiogenesis. However, to date, only limited knowledge exists with regard to the effects of endostatin on vessel morphology and the underlying signaling pathway. The aim of the present work was therefore to determine the impact of endostatin and its collagen XV analogue restin on vessel development during wound healing and embryonic angio- and vasculogenesis. Time lapse experiments and electron microscopy demonstrate similar morphological changes evoked by endostatin and the ERK1/2-kinase inhibitor PD98059. Furthermore, we show that ERK1/2 phosphorylation, a crucial signaling event in vascular morphogenesis, is regulated by endostatin via the protein phosphatase 2A PP2A. These findings provide new insight into a key signaling pathway of vascular remodeling evoked by a matrix-derived factor.",
keywords = "Angiogenesis Inhibitors, Animals, Cells, Cultured, Endostatins, Endothelial Cells, Female, MAP Kinase Signaling System, Mice, Mice, Inbred BALB C, Microtubule-Associated Proteins, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Neoplasm Proteins, Neovascularization, Physiologic, Recombinant Proteins, Wound Healing",
author = "Annette Schmidt and Daniela Wenzel and Irmgard Thorey and Takako Sasaki and J{\"u}rgen Hescheler and Rupert Timpl and Klaus Addicks and Sabine Werner and Fleischmann, {Bernd K} and Wilhelm Bloch",
year = "2006",
month = may,
day = "1",
doi = "10.1016/j.mvr.2006.01.001",
language = "English",
volume = "71",
pages = "152--162",
journal = "Microvascular research",
issn = "0026-2862",
publisher = "Academic Press Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction

AU - Schmidt, Annette

AU - Wenzel, Daniela

AU - Thorey, Irmgard

AU - Sasaki, Takako

AU - Hescheler, Jürgen

AU - Timpl, Rupert

AU - Addicks, Klaus

AU - Werner, Sabine

AU - Fleischmann, Bernd K

AU - Bloch, Wilhelm

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Endostatin, the proteolytic fragment of collagen XVIII, is known to be a potent inhibitor of angiogenesis. However, to date, only limited knowledge exists with regard to the effects of endostatin on vessel morphology and the underlying signaling pathway. The aim of the present work was therefore to determine the impact of endostatin and its collagen XV analogue restin on vessel development during wound healing and embryonic angio- and vasculogenesis. Time lapse experiments and electron microscopy demonstrate similar morphological changes evoked by endostatin and the ERK1/2-kinase inhibitor PD98059. Furthermore, we show that ERK1/2 phosphorylation, a crucial signaling event in vascular morphogenesis, is regulated by endostatin via the protein phosphatase 2A PP2A. These findings provide new insight into a key signaling pathway of vascular remodeling evoked by a matrix-derived factor.

AB - Endostatin, the proteolytic fragment of collagen XVIII, is known to be a potent inhibitor of angiogenesis. However, to date, only limited knowledge exists with regard to the effects of endostatin on vessel morphology and the underlying signaling pathway. The aim of the present work was therefore to determine the impact of endostatin and its collagen XV analogue restin on vessel development during wound healing and embryonic angio- and vasculogenesis. Time lapse experiments and electron microscopy demonstrate similar morphological changes evoked by endostatin and the ERK1/2-kinase inhibitor PD98059. Furthermore, we show that ERK1/2 phosphorylation, a crucial signaling event in vascular morphogenesis, is regulated by endostatin via the protein phosphatase 2A PP2A. These findings provide new insight into a key signaling pathway of vascular remodeling evoked by a matrix-derived factor.

KW - Angiogenesis Inhibitors

KW - Animals

KW - Cells, Cultured

KW - Endostatins

KW - Endothelial Cells

KW - Female

KW - MAP Kinase Signaling System

KW - Mice

KW - Mice, Inbred BALB C

KW - Microtubule-Associated Proteins

KW - Mitogen-Activated Protein Kinase 1

KW - Mitogen-Activated Protein Kinase 3

KW - Neoplasm Proteins

KW - Neovascularization, Physiologic

KW - Recombinant Proteins

KW - Wound Healing

U2 - 10.1016/j.mvr.2006.01.001

DO - 10.1016/j.mvr.2006.01.001

M3 - Journal articles

C2 - 16650878

VL - 71

SP - 152

EP - 162

JO - Microvascular research

JF - Microvascular research

SN - 0026-2862

IS - 3

ER -

ID: 70827