Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives

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Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives. / Zimmer, Philipp; Schenk, Alexander; Kieven, Markus; Holthaus, Michelle; Lehmann, Jonas; Lövenich, Lukas; Bloch, Wilhelm.

In: Exercise immunology review, Vol. 23, 2017, p. 66-81.

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@article{30e4d90bbaca4d54bb68ec3bc91d9503,
title = "Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives",
abstract = "With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.",
keywords = "Journal Article",
author = "Philipp Zimmer and Alexander Schenk and Markus Kieven and Michelle Holthaus and Jonas Lehmann and Lukas L{\"o}venich and Wilhelm Bloch",
note = "Copyright {\circledC} 2016 International Society of Exercise and Immunology. All rights reserved.",
year = "2017",
language = "English",
volume = "23",
pages = "66--81",
journal = "Exercise immunology review",
issn = "1077-5552",
publisher = "Human Kinetics Publishers Inc.",

}

RIS

TY - JOUR

T1 - Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives

AU - Zimmer, Philipp

AU - Schenk, Alexander

AU - Kieven, Markus

AU - Holthaus, Michelle

AU - Lehmann, Jonas

AU - Lövenich, Lukas

AU - Bloch, Wilhelm

N1 - Copyright © 2016 International Society of Exercise and Immunology. All rights reserved.

PY - 2017

Y1 - 2017

N2 - With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.

AB - With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.

KW - Journal Article

M3 - Journal articles

C2 - 28230531

VL - 23

SP - 66

EP - 81

JO - Exercise immunology review

JF - Exercise immunology review

SN - 1077-5552

ER -

ID: 3094567