Aiming at analytical method design, we studied the mass spectrometric dissociation behaviour of 5 isoquinoline-3-carboxamides that might potentially be clinically relevant HIF stabilisers according to literature data and patent specifications. Mass spectrometric information required for the development of analytical assays for HIF stabilisers with isoquinoline scaffold was gained by studying the collision induced dissociation behaviour of the five protonated model HIF-PHI 1 and 4-7. Herein, we exemplary discuss the CID of compound 1 in detail. Aus dem Text