Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

Anna Ulbricht, Sebastian Gehlert, Barbara Leciejewski, Thorsten Schiffer, Wilhelm Bloch, Jörg Höhfeld

Publication: Contribution to journalJournal articlesResearchpeer-review

Abstract

Chaperone-assisted selective autophagy (CASA) is a tension-induced degradation pathway essential for muscle maintenance. Impairment of CASA causes childhood muscle dystrophy and cardiomyopathy. However, the importance of CASA for muscle function in healthy individuals has remained elusive so far. Here we describe the impact of strength training on CASA in a group of healthy and moderately trained men. We show that strenuous resistance exercise causes an acute induction of CASA in affected muscles to degrade mechanically damaged cytoskeleton proteins. Moreover, repeated resistance exercise during 4 wk of training led to an increased expression of CASA components. In human skeletal muscle, CASA apparently acts as a central adaptation mechanism that responds to acute physical exercise and to repeated mechanical stimulation.

Original languageEnglish
JournalAutophagy
Volume11
Issue number3
Pages (from-to)538-546
Number of pages9
ISSN1554-8627
DOIs
Publication statusPublished - 01.01.2015

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