Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents

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Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents. / Wunram, Heidrun Lioba; Hamacher, Stefanie; Oberste, Max; Neufang, Susanne; Belke, Luisa; Jänicke, Franziska; Graf, Christine; Schönau, Eckhard; Bender, Stephan; Fricke, Oliver.

In: European child & adolescent psychiatry, 12.03.2021.

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@article{e3644bea36e149e28f117afbd92d88f8,
title = "Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents",
abstract = "Recent meta-analyses reveal a moderate effect of physical activity (PA) in the treatment of adolescent depression. However, not only the underlying neurobiological mechanisms, also the influences of placebo-related motivational factors (beliefs and expectancies in sporting, enjoyment and prior sports experiences), are still unclear. Based on the data of our prior study {"}Mood Vibes{"}, we hypothesized that placebo-inherent factors like positive prior sports experiences and motivational factors, (positive beliefs, expectancies, and enjoyment related to PA), would increase the effects of an add-on exercise-therapy in juvenile depression. From 64 included depressed adolescents, 41 underwent an intensive add-on PA-therapy. Motivational factors were assessed using sport-specific scales. The changes in depression scores under treatment were rated by self-rating scale (German {"}Childhood Depression Inventory{"}, (DIKJ)). A mixed model for repeated measures (MMRM) was used to analyze the effects of the different motivational variates on DIKJ. While prior sports experiences had no impact, motivational factors showed a significant effect on PA-induced changes in DIKJ scores (p = 0.002). The demotivated participants improved less, whereas it was sufficient to be neutral towards sporting to benefit significantly more. Motivational placebo-related factors (beliefs, expectancies and enjoyment regarding PA) affected the outcomes of an exercise treatment in depressed adolescents. Yet, a neutral mindset was sufficient to profit more from PA. Prior sporting in the sense of positive conditioning and as a protective factor did not play a role. Knowledge about these influences could in a second step help to develop tailored therapies.",
author = "Wunram, {Heidrun Lioba} and Stefanie Hamacher and Max Oberste and Susanne Neufang and Luisa Belke and Franziska J{\"a}nicke and Christine Graf and Eckhard Sch{\"o}nau and Stephan Bender and Oliver Fricke",
year = "2021",
month = mar,
day = "12",
doi = "10.1007/s00787-021-01742-5",
language = "English",
journal = "European child & adolescent psychiatry",
issn = "1435-165X",
publisher = "D. Steinkopff-Verlag",

}

RIS

TY - JOUR

T1 - Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents

AU - Wunram, Heidrun Lioba

AU - Hamacher, Stefanie

AU - Oberste, Max

AU - Neufang, Susanne

AU - Belke, Luisa

AU - Jänicke, Franziska

AU - Graf, Christine

AU - Schönau, Eckhard

AU - Bender, Stephan

AU - Fricke, Oliver

PY - 2021/3/12

Y1 - 2021/3/12

N2 - Recent meta-analyses reveal a moderate effect of physical activity (PA) in the treatment of adolescent depression. However, not only the underlying neurobiological mechanisms, also the influences of placebo-related motivational factors (beliefs and expectancies in sporting, enjoyment and prior sports experiences), are still unclear. Based on the data of our prior study "Mood Vibes", we hypothesized that placebo-inherent factors like positive prior sports experiences and motivational factors, (positive beliefs, expectancies, and enjoyment related to PA), would increase the effects of an add-on exercise-therapy in juvenile depression. From 64 included depressed adolescents, 41 underwent an intensive add-on PA-therapy. Motivational factors were assessed using sport-specific scales. The changes in depression scores under treatment were rated by self-rating scale (German "Childhood Depression Inventory", (DIKJ)). A mixed model for repeated measures (MMRM) was used to analyze the effects of the different motivational variates on DIKJ. While prior sports experiences had no impact, motivational factors showed a significant effect on PA-induced changes in DIKJ scores (p = 0.002). The demotivated participants improved less, whereas it was sufficient to be neutral towards sporting to benefit significantly more. Motivational placebo-related factors (beliefs, expectancies and enjoyment regarding PA) affected the outcomes of an exercise treatment in depressed adolescents. Yet, a neutral mindset was sufficient to profit more from PA. Prior sporting in the sense of positive conditioning and as a protective factor did not play a role. Knowledge about these influences could in a second step help to develop tailored therapies.

AB - Recent meta-analyses reveal a moderate effect of physical activity (PA) in the treatment of adolescent depression. However, not only the underlying neurobiological mechanisms, also the influences of placebo-related motivational factors (beliefs and expectancies in sporting, enjoyment and prior sports experiences), are still unclear. Based on the data of our prior study "Mood Vibes", we hypothesized that placebo-inherent factors like positive prior sports experiences and motivational factors, (positive beliefs, expectancies, and enjoyment related to PA), would increase the effects of an add-on exercise-therapy in juvenile depression. From 64 included depressed adolescents, 41 underwent an intensive add-on PA-therapy. Motivational factors were assessed using sport-specific scales. The changes in depression scores under treatment were rated by self-rating scale (German "Childhood Depression Inventory", (DIKJ)). A mixed model for repeated measures (MMRM) was used to analyze the effects of the different motivational variates on DIKJ. While prior sports experiences had no impact, motivational factors showed a significant effect on PA-induced changes in DIKJ scores (p = 0.002). The demotivated participants improved less, whereas it was sufficient to be neutral towards sporting to benefit significantly more. Motivational placebo-related factors (beliefs, expectancies and enjoyment regarding PA) affected the outcomes of an exercise treatment in depressed adolescents. Yet, a neutral mindset was sufficient to profit more from PA. Prior sporting in the sense of positive conditioning and as a protective factor did not play a role. Knowledge about these influences could in a second step help to develop tailored therapies.

U2 - 10.1007/s00787-021-01742-5

DO - 10.1007/s00787-021-01742-5

M3 - Journal articles

C2 - 33709258

JO - European child & adolescent psychiatry

JF - European child & adolescent psychiatry

SN - 1435-165X

ER -

ID: 5908353