Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training

Research output: Contribution to journalJournal articlesResearchpeer-review

Authors

Research units

Details

Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS. Further research is warranted to investigate whether these changes are associated with clinical measures (e.g. depressions and immune function).

Original languageEnglish
JournalJournal of neuroimmunology
Volume314
Pages (from-to)101-105
Number of pages5
ISSN0165-5728
DOIs
Publication statusPublished - 15.01.2018

ID: 3263666

View graph of relations