Abstract
Athletes with a T/EpiT ratio higher than 4 are suspicious for the intake of synthetic anabolic androgenous steroids. In order to find out whether the T/EpiT ratio occurs naturally or is due to a doping offence, the urine samples are measured by GC/C/IRMS. The δ13 C-values of the main testosterone metabolites and the endogenous reference compounds are compared. If any measured ∆δ value between an endogenous reference and a target compound is not larger than 3‰ a naturally elevated T/EpiT ratio is assumed. After lowering the critical threshold from T/EpiT > 6 to T/EpiT > 4 by WADA in 2004 the number of samples measured by GC/C/IRMS in Cologne increased more than two-fold. The presented dataset consists of n = 331 samples from Cologne and n = 246 samples from other laboratories, mainly from out of Europe. The total number of doping control samples confirmed by IRMS was n = 603 with n = 34 IRMS–positive results. Although the dietary status throughout Europe is assumed to be quite similar, it is possible to set up groups of related δ13 C-values depending on the geographical origin of the sample. They were sorted by the laboratories which sent the samples for IRMS–analysis to Cologne. These groups have different mean values but statistically are not significantly different whereas samples from South Africa or South America exhibit obviously different values. Verf.-Referat
Original language | English |
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Title of host publication | Recent advances in doping analysis (14) : Proceedings of the Manfred Donike Workshop ; 24th Cologne Workshop on Dope Analysis 4th to 9th June 2006 |
Editors | Wilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck |
Number of pages | 10 |
Publisher | Sport & Buch Strauß |
Publication date | 2006 |
Pages | 289-298 |
Publication status | Published - 2006 |
Event | Cologne Workshop on Dope Analysis - Köln, Germany Duration: 04.06.2006 → 09.06.2006 Conference number: 24 |