Presentation of the IRMS results of suspicious samples with elevated T/EpiT ratios in 2005

Publication: Chapter in Book/Report/Conference proceedingConference contribution - Article for conferenceResearch

Abstract

Athletes with a T/EpiT ratio higher than 4 are suspicious for the intake of synthetic anabolic androgenous steroids. In order to find out whether the T/EpiT ratio occurs naturally or is due to a doping offence, the urine samples are measured by GC/C/IRMS. The δ13 C-values of the main testosterone metabolites and the endogenous reference compounds are compared. If any measured ∆δ value between an endogenous reference and a target compound is not larger than 3‰ a naturally elevated T/EpiT ratio is assumed. After lowering the critical threshold from T/EpiT > 6 to T/EpiT > 4 by WADA in 2004 the number of samples measured by GC/C/IRMS in Cologne increased more than two-fold. The presented dataset consists of n = 331 samples from Cologne and n = 246 samples from other laboratories, mainly from out of Europe. The total number of doping control samples confirmed by IRMS was n = 603 with n = 34 IRMS–positive results. Although the dietary status throughout Europe is assumed to be quite similar, it is possible to set up groups of related δ13 C-values depending on the geographical origin of the sample. They were sorted by the laboratories which sent the samples for IRMS–analysis to Cologne. These groups have different mean values but statistically are not significantly different whereas samples from South Africa or South America exhibit obviously different values. Verf.-Referat
Original languageEnglish
Title of host publicationRecent advances in doping analysis (14) : Proceedings of the Manfred Donike Workshop ; 24th Cologne Workshop on Dope Analysis 4th to 9th June 2006
EditorsWilhelm Schänzer, Hans Geyer, A. Gotzmann, Ute Mareck
Number of pages10
PublisherSport & Buch Strauß
Publication date2006
Pages289-298
Publication statusPublished - 2006
EventCologne Workshop on Dope Analysis - Köln, Germany
Duration: 04.06.200609.06.2006
Conference number: 24

Fingerprint

Dive into the research topics of 'Presentation of the IRMS results of suspicious samples with elevated T/EpiT ratios in 2005'. Together they form a unique fingerprint.

Citation