The influence of microgravity on cerebral blood flow and electrocortical activity

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The influence of microgravity on cerebral blood flow and electrocortical activity. / Klein, Timo; Wollseiffen, Petra; Sanders, Marit L; Claassen, Jurgen; Carnahan, Heather; Abeln, Vera; Vogt, Tobias; Strüder, Heiko Klaus; Schneider, Stefan.

In: Experimental brain research, Vol. 237, No. 4, 08.04.2019, p. 1057-1062.

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@article{667d479afd114dd0898168bf691d30ae,
title = "The influence of microgravity on cerebral blood flow and electrocortical activity",
abstract = "Changes in gravity conditions have previously been reported to influence brain hemodynamics as well as neuronal activity. This paper attempts to identify a possible link between changes in brain blood flow and neuronal activity during microgravity. Middle cerebral artery flow velocity (MCAv) was measured using Doppler ultrasound. Brain cortical activity (i.e., cortical current density) was measured using electroencephalography. Finger blood pressure was recorded and exported to generate beat-by-beat systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and cerebrovascular conductance index (CVCi). Seventeen participants were evaluated under normal gravity conditions and microgravity conditions, during 15 bouts of 22-s intervals of weightlessness during a parabolic flight. Although MAP decreased and CO increased, MCAv remained unchanged in the microgravity condition. CVCi as the quotient of MCAv and MAP increased in microgravity. Cortical current density showed a global decrease. Our data support earlier data reporting a decrease in the amplitude of event-related potentials recorded during microgravity. However, the general decrease in neural excitability in microgravity seems not to be dependent on hemodynamic changes.",
keywords = "EEG, MCA, Parabolic flight, Transcranial Doppler ultrasound",
author = "Timo Klein and Petra Wollseiffen and Sanders, {Marit L} and Jurgen Claassen and Heather Carnahan and Vera Abeln and Tobias Vogt and Str{\"u}der, {Heiko Klaus} and Stefan Schneider",
year = "2019",
month = apr,
day = "8",
doi = "10.1007/s00221-019-05490-6",
language = "English",
volume = "237",
pages = "1057--1062",
journal = "Experimental brain research",
issn = "0014-4819",
publisher = "Springer Verlag",
number = "4",

}

RIS

TY - JOUR

T1 - The influence of microgravity on cerebral blood flow and electrocortical activity

AU - Klein, Timo

AU - Wollseiffen, Petra

AU - Sanders, Marit L

AU - Claassen, Jurgen

AU - Carnahan, Heather

AU - Abeln, Vera

AU - Vogt, Tobias

AU - Strüder, Heiko Klaus

AU - Schneider, Stefan

PY - 2019/4/8

Y1 - 2019/4/8

N2 - Changes in gravity conditions have previously been reported to influence brain hemodynamics as well as neuronal activity. This paper attempts to identify a possible link between changes in brain blood flow and neuronal activity during microgravity. Middle cerebral artery flow velocity (MCAv) was measured using Doppler ultrasound. Brain cortical activity (i.e., cortical current density) was measured using electroencephalography. Finger blood pressure was recorded and exported to generate beat-by-beat systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and cerebrovascular conductance index (CVCi). Seventeen participants were evaluated under normal gravity conditions and microgravity conditions, during 15 bouts of 22-s intervals of weightlessness during a parabolic flight. Although MAP decreased and CO increased, MCAv remained unchanged in the microgravity condition. CVCi as the quotient of MCAv and MAP increased in microgravity. Cortical current density showed a global decrease. Our data support earlier data reporting a decrease in the amplitude of event-related potentials recorded during microgravity. However, the general decrease in neural excitability in microgravity seems not to be dependent on hemodynamic changes.

AB - Changes in gravity conditions have previously been reported to influence brain hemodynamics as well as neuronal activity. This paper attempts to identify a possible link between changes in brain blood flow and neuronal activity during microgravity. Middle cerebral artery flow velocity (MCAv) was measured using Doppler ultrasound. Brain cortical activity (i.e., cortical current density) was measured using electroencephalography. Finger blood pressure was recorded and exported to generate beat-by-beat systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), and cerebrovascular conductance index (CVCi). Seventeen participants were evaluated under normal gravity conditions and microgravity conditions, during 15 bouts of 22-s intervals of weightlessness during a parabolic flight. Although MAP decreased and CO increased, MCAv remained unchanged in the microgravity condition. CVCi as the quotient of MCAv and MAP increased in microgravity. Cortical current density showed a global decrease. Our data support earlier data reporting a decrease in the amplitude of event-related potentials recorded during microgravity. However, the general decrease in neural excitability in microgravity seems not to be dependent on hemodynamic changes.

KW - EEG

KW - MCA

KW - Parabolic flight

KW - Transcranial Doppler ultrasound

UR - https://www.mendeley.com/catalogue/fa06d1df-3765-3e12-bc8f-1708963853d4/

U2 - 10.1007/s00221-019-05490-6

DO - 10.1007/s00221-019-05490-6

M3 - Journal articles

VL - 237

SP - 1057

EP - 1062

JO - Experimental brain research

JF - Experimental brain research

SN - 0014-4819

IS - 4

ER -

ID: 3647483